Rob Herring, CJ Stander and Quinn Roux have been included in the 34-man lineup of the Autumn National Cup for the first time this year.
In addition to selecting from three South African new players, coach Andy Farrell has also selected three uncapped players in the back: Shane Daly (Munster), Billy Burns (Ulster) and James Lowe (Leinster).
The squad will meet again on Thursday at the IRFU High Performance Center in Blanchardstown to prepare for the upcoming test matches in Ireland.
On Friday 13 November, Ireland will compete against Wales at home, and then travel to London to play with England at Twickenham on 21 November 2020.
The next Sunday, Ireland will host Georgia at Aviva Stadium in Georgia and will complete a series of international matches against Fiji, France, Italy or Scotland on Saturday, December 5.
Finlay Bealham, Tadhg Beirne, Ed Byrne, Will Connors, Ultan Dillane, Caelan Doris, Cian Healy, Dave Heffernan, Iain Henderson , Rob Herring, Ronan Kelleher, Peter O’Mahony, Andrew Porter, Quinn Roux, John Ryan, James Ryan, CJ Stander, Josh van der Flier
Bundee Aki , Billy Burns, Ross Byrne, Andrew Conway, Shane Daly, Keith Earls, Chris Farrell, Jamison Gibson Park, Robbie Henshaw, Hugo Keenan, James Lowe, Kieran Marmion, Stuart McCloskey, Conor Murray, Jonathan Sexton (Captain), Jacob Stockdale